@article{954671399a5c477eb9ebcd58b18935df,
title = "Chiral pyrophosphoric acid catalysts for the para-selective and enantioselective aza-friedel-crafts reaction of phenols",
abstract = "Chiral BINOL-derived pyrophosphoric acid catalysts were developed and used for the regio- and enantioselective aza-Friedel-Crafts reaction of phenols with aldimines. ortho/para-Directing phenols could react at the para-position selectively with moderate to good enantioselectivities. Moreover, the gram-scale transformation of a product into the key intermediate for the antifungal agent (R)-bifonazole was demonstrated.",
keywords = "Aza-Friedel-Crafts reaction, Br{\o}nsted acid, Or-ganocatalyst, Phenol, Phosphoric acid, Pyrophosphoric acid, Regio-selectivity",
author = "Haruka Okamoto and Kohei Toh and Takuya Mochizuki and Hidefumi Nakatsuji and Akira Sakakura and Manabu Hatano and Kazuaki Ishihara",
note = "Funding Information: This work was financially supported by JSPS KAKENHI Grant Numbers JP26288046, JP17H03054, and JP15H05810 in Precisely Designed Catalysts with Customized Scaffolding.() Publisher Copyright: {\textcopyright} Georg Thieme Verlag Stuttgart · New York.",
year = "2018",
doi = "10.1055/s-0037-1610250",
language = "English",
volume = "50",
pages = "4577--4590",
journal = "Synthesis",
issn = "0039-7881",
publisher = "Georg Thieme Verlag",
number = "23",
}