Chloroplast DNA dynamics: Copy number, quality control and degradation

Wataru Sakamoto, Tsuneaki Takami


41 被引用数 (Scopus)


Endosymbiotically originated chloroplast DNA (cpDNA) encodes part of the genetic information needed to fulfill chloroplast function, including fundamental processes such as photosynthesis. In the last two decades, advances in genome analysis led to the identification of a considerable number of cpDNA sequences from various species. While these data provided the consensus features of cpDNA organization and chloroplast evolution in plants, how cpDNA is maintained through development and is inherited remains to be fully understood. In particular, the fact that cpDNA exists as multiple copies despite its limited genetic capacity raises the important question of how copy number is maintained or whether cpDNA is subjected to quantitative fluctuation or even developmental degradation. For example, cpDNA is abundant in leaves, where it forms punctate structures called nucleoids, which seemingly alter their morphologies and numbers depending on the developmental status of the chloroplast. In this review, we summarize our current understanding of 'cpDNA dynamics', focusing on the changes in DNA abundance. A special focus is given to the cpDNA degradation mechanism, which appears to be mediated by Defective in Pollen organelle DNA degradation 1 (DPD1), a recently discovered organelle exonuclease. The physiological significance of cpDNA degradation in flowering plants is also discussed.

ジャーナルPlant and Cell Physiology
出版ステータスPublished - 6月 1 2018

ASJC Scopus subject areas

  • 生理学
  • 植物科学
  • 細胞生物学


「Chloroplast DNA dynamics: Copy number, quality control and degradation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。