Chronic administration of acetylcholinesterase inhibitor in the senescent Rat brain

K. Tanaka, N. Ogawa, M. Asanuma, Yoichi Kondo, A. Mori


23 被引用数 (Scopus)


The effects of chronic administration of ENA-713, an acetylcholinesterase (AChE) inhibitor, on pre- and postsynaptic cholinergic indices were examined in the senescent rat brain. In the senescent group, the acetylcholine (ACh) level was markedly reduced in the frontal cortex, hippocampus, striatum and thalamus + midbrain, but these reductions were completely prevented by ENA-713. Moreover, although choline acetyltransferase (ChAT) activity was also significantly decreased in these four regions, it recovered in the frontal cortex, hippocampus and thalamus + midbrain after ENA-713 treatment. In contrast, cholinesterase (ChE) activity was not changed in any experimental groups. The maximum number (Bmax) of muscarinic M1 receptor (M1-R) binding site in the frontal cortex in the senescent group was decreased without any change in affinity, but this decrease was also inhibited by ENA-713. Thus, these findings suggest that ENA-713 may have protective, neurotrophic and therapeutic effects on aging-induced cholinergic dysfunction and be useful for the treatment of aging-related dementia, such as the Alzheimer-type dementia.

ジャーナルNeurobiology of Aging
出版ステータスPublished - 1月 1 1994

ASJC Scopus subject areas

  • 神経科学一般
  • 加齢科学
  • 臨床神経学
  • 発生生物学
  • 老年医学


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