Chronic administration of acetylcholinesterase inhibitor in the senescent Rat brain

K. Tanaka, N. Ogawa, M. Asanuma, Yoichi Kondo, A. Mori

研究成果査読

23 被引用数 (Scopus)

抄録

The effects of chronic administration of ENA-713, an acetylcholinesterase (AChE) inhibitor, on pre- and postsynaptic cholinergic indices were examined in the senescent rat brain. In the senescent group, the acetylcholine (ACh) level was markedly reduced in the frontal cortex, hippocampus, striatum and thalamus + midbrain, but these reductions were completely prevented by ENA-713. Moreover, although choline acetyltransferase (ChAT) activity was also significantly decreased in these four regions, it recovered in the frontal cortex, hippocampus and thalamus + midbrain after ENA-713 treatment. In contrast, cholinesterase (ChE) activity was not changed in any experimental groups. The maximum number (Bmax) of muscarinic M1 receptor (M1-R) binding site in the frontal cortex in the senescent group was decreased without any change in affinity, but this decrease was also inhibited by ENA-713. Thus, these findings suggest that ENA-713 may have protective, neurotrophic and therapeutic effects on aging-induced cholinergic dysfunction and be useful for the treatment of aging-related dementia, such as the Alzheimer-type dementia.

本文言語English
ページ(範囲)721-725
ページ数5
ジャーナルNeurobiology of Aging
15
6
DOI
出版ステータスPublished - 1月 1 1994

ASJC Scopus subject areas

  • 神経科学一般
  • 加齢科学
  • 臨床神経学
  • 発生生物学
  • 老年医学

フィンガープリント

「Chronic administration of acetylcholinesterase inhibitor in the senescent Rat brain」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル