TY - JOUR
T1 - Coagulation testing method using magnetic nanoparticles
AU - Yamashita, Kei
AU - Naito, Kosuke
AU - Wang, Jin
AU - Kasuda, Shogo
AU - Kiwa, Toshihiko
N1 - Publisher Copyright:
© 2025 The Author(s). Published on behalf of The Japan Society of Applied Physics by IOP Publishing Ltd.
PY - 2025/2/1
Y1 - 2025/2/1
N2 - This study presents a blood coagulation test method based on magnetic nanoparticles (MNPs) undergoing Brownian relaxation in response to a magnetic field. Because Brownian relaxation depends on viscosity and particle volume, coagulation and MNP aggregation need to be separately evaluated. We assess the effects of coagulation and aggregation on the basis of alternating current susceptibility of MNPs. The magnetic signal is observed to considerably increase to 177 ± 3.71 μV in the case with coagulation, compared with only 133 ± 3.87 μV in the case without coagulation, thereby indicating that coagulation inhibits ion-induced aggregation of MNPs.
AB - This study presents a blood coagulation test method based on magnetic nanoparticles (MNPs) undergoing Brownian relaxation in response to a magnetic field. Because Brownian relaxation depends on viscosity and particle volume, coagulation and MNP aggregation need to be separately evaluated. We assess the effects of coagulation and aggregation on the basis of alternating current susceptibility of MNPs. The magnetic signal is observed to considerably increase to 177 ± 3.71 μV in the case with coagulation, compared with only 133 ± 3.87 μV in the case without coagulation, thereby indicating that coagulation inhibits ion-induced aggregation of MNPs.
KW - AC susceptibility
KW - blood coagulation
KW - magnetic materials
KW - magnetic nanoparticles
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U2 - 10.35848/1347-4065/adaba5
DO - 10.35848/1347-4065/adaba5
M3 - Article
AN - SCOPUS:85218470241
SN - 0021-4922
VL - 64
JO - Japanese Journal of Applied Physics
JF - Japanese Journal of Applied Physics
IS - 2
M1 - 020902
ER -