TY - JOUR
T1 - Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain
AU - Kaneko, Masahisa
AU - Abe, Koji
AU - Kogure, Kyuya
AU - Saito, Hiroshi
AU - Matsuki, Norio
PY - 1993/7/23
Y1 - 1993/7/23
N2 - The effects of electroconvulsive seizure and anti-convulsant drugs on induction of mRNA of heat shock protein were studied in mouse brain. Electrical shock induced mRNA of heat shock cognate protein (HSC70), but not heat shock protein (HSP70) mRNA. The induction was maximum 1 h after the ECS and continued for several hours, followed by long-lasting depression. Diazepam slightly prevented the ECS, but strongly attenuated the induction of HSC70 mRNA. Whereas phenytoin, which blocked the seizure, did not decrease but delayed the induction of HSC70 mRNA. The present results suggest that HSC70 mRNA level is increased with the ECS and that the induction level did not necessarily correlate the severity of the seizure.
AB - The effects of electroconvulsive seizure and anti-convulsant drugs on induction of mRNA of heat shock protein were studied in mouse brain. Electrical shock induced mRNA of heat shock cognate protein (HSC70), but not heat shock protein (HSP70) mRNA. The induction was maximum 1 h after the ECS and continued for several hours, followed by long-lasting depression. Diazepam slightly prevented the ECS, but strongly attenuated the induction of HSC70 mRNA. Whereas phenytoin, which blocked the seizure, did not decrease but delayed the induction of HSC70 mRNA. The present results suggest that HSC70 mRNA level is increased with the ECS and that the induction level did not necessarily correlate the severity of the seizure.
KW - Diazepam
KW - Electroconvulsive seizure
KW - Heat shock cognate protein
KW - Heat shock protein
KW - Mouse
KW - Northern blot hybridization
KW - Phenytoin
KW - Time course
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U2 - 10.1016/0304-3940(93)90735-4
DO - 10.1016/0304-3940(93)90735-4
M3 - Article
C2 - 8233052
AN - SCOPUS:0027313061
SN - 0304-3940
VL - 157
SP - 195
EP - 198
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -