Critical appraisal of the 1977 diagnostic criteria for minamata disease

Takashi Yorifuji, Toshihide Tsuda, Sachiko Inoue, Soshi Takao, Masazumi Harada, Ichiro Kawachi

研究成果査読

14 被引用数 (Scopus)

抄録

Large-scale food poisoning caused bymethylmercury was identified in Minamata, Japan, in the 1950s (Minamata disease). Although the diagnostic criteria for the disease remain current, few studies have been carried out to assess the diagnostic accuracy of the criteria. From a 1971 populationbased investigation, data from 2 villages were selected: Minamata (high-exposure area; n = 779) and Ariake (low-exposure area; n = 755). The authors examined the prevalence of neurologic signs characteristic of methylmercury poisoning and the validity of the criteria. A substantial number of residents in the exposed area exhibited neurologic signs even after excluding officially certified patients. Using paresthesia of the extremities as the gold standard of diagnosis, the criteria had a sensitivity of 66%. The current diagnostic criteria as well as the official certification system substantially underestimate the incidence of Minamata disease.

本文言語English
ページ(範囲)22-29
ページ数8
ジャーナルArchives of Environmental and Occupational Health
68
1
DOI
出版ステータスPublished - 2013

ASJC Scopus subject areas

  • 毒物学
  • 環境科学一般
  • 公衆衛生学、環境および労働衛生
  • 健康、毒物学および変異誘発

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