TY - JOUR
T1 - Cytokines and chemokines
T2 - Roles in the pathophysiology and therapy of ischemia and reperfusion injury
AU - Araki, Motoo
AU - Schenk, Austin D.
AU - Fairchild, Robert L.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - The understanding of ischemia and reperfusion injury grows, but the search for the critical early regulators of the ischemia and reperfusion injury process remains difficult. The current therapies to attenuate ischemia and reperfusion injury are overwhelming, but the subtleties of the injury and of human medicine prevent immediate clinical implementation. Cytokineand chemokine-targeted therapies to circumvent ischemia and reperfusion injury in transplanted organs hold promise for the future.
AB - The understanding of ischemia and reperfusion injury grows, but the search for the critical early regulators of the ischemia and reperfusion injury process remains difficult. The current therapies to attenuate ischemia and reperfusion injury are overwhelming, but the subtleties of the injury and of human medicine prevent immediate clinical implementation. Cytokineand chemokine-targeted therapies to circumvent ischemia and reperfusion injury in transplanted organs hold promise for the future.
KW - Chemokines
KW - Cytokines
KW - Ischemia and reperfusion injury
KW - Macrophages
KW - Neutrophils
UR - http://www.scopus.com/inward/record.url?scp=35848933471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35848933471&partnerID=8YFLogxK
U2 - 10.1097/01.mot.0000127627.94212.76
DO - 10.1097/01.mot.0000127627.94212.76
M3 - Review article
AN - SCOPUS:35848933471
SN - 1087-2418
VL - 9
SP - 139
EP - 144
JO - Current Opinion in Organ Transplantation
JF - Current Opinion in Organ Transplantation
IS - 2
ER -
