Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

Kenichi Kobayashi; Yusuke Fujii; Yuichiro Hirayama; Shinichi Kobayashi; Ichiro Hayakawa; Hideo Kigoshi

doi:10.1021/ol300182r

Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

Kenichi Kobayashi, Yusuke Fujii, Yuichiro Hirayama, Shinichi Kobayashi, Ichiro Hayakawa, Hideo Kigoshi

工学部

研究成果 › 査読

27 被引用数 (Scopus)

抄録

A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity.

本文言語	English
ページ（範囲）	1290-1293
ページ数	4
ジャーナル	Organic Letters
巻	14
号	5
DOI	https://doi.org/10.1021/ol300182r
出版ステータス	Published - 3月 2 2012

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol300182r

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AU - Hayakawa, Ichiro

AU - Kigoshi, Hideo

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N2 - A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity.

AB - A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity.

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Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

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