Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

Hisao Higo; Keiichi Fujiwara; Hiromi Watanabe; Go Makimoto; Nobuhisa Kameyama; Mizuho Matsushita; Kanmei Rai; Ken Sato; Tomoko Inomata; Kazutaka Sunami; Takuo Shibayama

doi:10.2169/internalmedicine.53.1728

Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

Hisao Higo, Keiichi Fujiwara, Hiromi Watanabe, Go Makimoto, Nobuhisa Kameyama, Mizuho Matsushita, Kanmei Rai, Ken Sato, Tomoko Inomata, Kazutaka Sunami, Takuo Shibayama

岡山大学病院

研究成果 › 査読

4 被引用数 (Scopus)

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A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

本文言語	English
ページ（範囲）	1809-1812
ページ数	4
ジャーナル	Internal Medicine
巻	53
号	16
DOI	https://doi.org/10.2169/internalmedicine.53.1728
出版ステータス	Published - 2014

ASJC Scopus subject areas

内科学

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10.2169/internalmedicine.53.1728

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title = "Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy",

abstract = "A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.",

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T1 - Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

AU - Higo, Hisao

AU - Fujiwara, Keiichi

AU - Watanabe, Hiromi

AU - Makimoto, Go

AU - Kameyama, Nobuhisa

AU - Matsushita, Mizuho

AU - Rai, Kanmei

AU - Sato, Ken

AU - Inomata, Tomoko

AU - Sunami, Kazutaka

AU - Shibayama, Takuo

PY - 2014

Y1 - 2014

N2 - A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

AB - A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

KW - Bortezomib

KW - Diffuse parenchymal pulmonary amyloidosis

KW - Ground glass attenuation

KW - Multiple myeloma

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Diffuse parenchymal pulmonary amyloidosis showing an objective response to bortezomib-based chemotherapy

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