Discoidin domain receptor 1: A new class of receptor regulating leukocyte-collagen interaction

Teizo Yoshimura, Wataru Matsuyama, Hidenobu Kamohara

研究成果査読

40 被引用数 (Scopus)

抄録

Previous studies demonstrated that type I collagen, a major component of the extracellular matrix, could influence the differentiation and function of leukocytes; however, it is not clear whether those effects of collagen were based on its interaction with the classic collagen receptors, α1β1 and α2β1 integrins. We recently detected significant upregulation of discoidin domain receptor 1 (DDR1), a new class of collagen receptor, in human leukocytes, including neutrophils, monocytes, and lymphocytes, in vitro, leading to the hypothesis that the leukocyte-activating effects of collagen might be owing to its interaction with DDR1. In this review, we summarize our recent findings demonstrating that DDR1-collagen interaction facilitates the adhesion, migration, differentiation/maturation, and cytokine/chemokine production of leukocytes. We also describe the intracellular signaling pathways activated by DDR1 interaction with collagen.

本文言語English
ページ(範囲)219-229
ページ数11
ジャーナルImmunologic Research
31
3
DOI
出版ステータスPublished - 2005
外部発表はい

ASJC Scopus subject areas

  • 免疫学

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