TY - JOUR
T1 - Dual-time-point F-18 FDG PET/CT for evaluation in patients with malignant lymphoma
AU - Shinya, Takayoshi
AU - Fujii, Soichiro
AU - Asakura, Shoji
AU - Taniguchi, Toshitaka
AU - Yoshio, Kotaro
AU - Alafate, Aierken
AU - Sato, Shuhei
AU - Yoshino, Tadashi
AU - Kanazawa, Susumu
N1 - Funding Information:
Conflict of interest This work has received no funding from any of the following organization: National Institutes of Health; Wellcome Trust; Howard Hughes Medical Institute; and others.
PY - 2012/10
Y1 - 2012/10
N2 - Objective The aim of this study was to evaluate the usefulness of F-18 fluorodeoxyglucose (FDG) dual-timepoint (DTP) positron emission tomography (PET)/computed tomography (CT) with semiquantitative analyses for the initial staging in patients with malignant lymphoma. Methods Forty-three patients had DTP PET/CT, with 60-min and 2-h scan [n = 8, Hodgkin's lymphoma (HL); n = 12, indolent non-Hodgkin lymphoma (NHL); n = 23, aggressive NHL]. Results A total of 524 lesions were evaluated (406 lymph nodes and 118 extra-nodal lesions). The maximum standardized uptake value (SUVmax) on 2-h delayed scan (SUV2) was significantly higher than those on 1-h early scan (SUV1) for all groups (P<0.0001 for HL; P<0.0001 for indolent NHL; P<0.0001 for aggressive NHL). Significant differences were detected between HL and indolent NHL, between indolent NHL and the aggressive NHL for both SUV1 and SUV2 (each P<0.0001). No significant differences were detected between HL and aggressive NHL for both SUV1 and SUV2 (P = 0.6891 for SUV1; P = 0.8828 for SUV 2); however, significant differences were detected for the retention index of SUVmax between these groups (P = 0.0238). Conclusions DTP F-18 FDG PET/CT with a semiquantitative technique may have the potential to provide the more accurate diagnoses for the staging of malignant lymphoma and the more important role in predicting the histological grades of malignancy compared with singletime- point F-18 FDG-PET scan.
AB - Objective The aim of this study was to evaluate the usefulness of F-18 fluorodeoxyglucose (FDG) dual-timepoint (DTP) positron emission tomography (PET)/computed tomography (CT) with semiquantitative analyses for the initial staging in patients with malignant lymphoma. Methods Forty-three patients had DTP PET/CT, with 60-min and 2-h scan [n = 8, Hodgkin's lymphoma (HL); n = 12, indolent non-Hodgkin lymphoma (NHL); n = 23, aggressive NHL]. Results A total of 524 lesions were evaluated (406 lymph nodes and 118 extra-nodal lesions). The maximum standardized uptake value (SUVmax) on 2-h delayed scan (SUV2) was significantly higher than those on 1-h early scan (SUV1) for all groups (P<0.0001 for HL; P<0.0001 for indolent NHL; P<0.0001 for aggressive NHL). Significant differences were detected between HL and indolent NHL, between indolent NHL and the aggressive NHL for both SUV1 and SUV2 (each P<0.0001). No significant differences were detected between HL and aggressive NHL for both SUV1 and SUV2 (P = 0.6891 for SUV1; P = 0.8828 for SUV 2); however, significant differences were detected for the retention index of SUVmax between these groups (P = 0.0238). Conclusions DTP F-18 FDG PET/CT with a semiquantitative technique may have the potential to provide the more accurate diagnoses for the staging of malignant lymphoma and the more important role in predicting the histological grades of malignancy compared with singletime- point F-18 FDG-PET scan.
KW - Delayed scan
KW - Dual-time-point (DTP)
KW - F-18 FDG
KW - Malignant lymphoma
KW - PET/CT
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U2 - 10.1007/s12149-012-0619-y
DO - 10.1007/s12149-012-0619-y
M3 - Article
C2 - 22692457
AN - SCOPUS:84867992350
SN - 0914-7187
VL - 26
SP - 616
EP - 621
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
IS - 8
ER -