TY - JOUR
T1 - Effect of ceruletide on epileptogenesis in amygdaloid kindled rats
AU - Yamamoto, Yoshitaka
AU - Itano, Toshifumi
AU - Miyamoto, Osamu
AU - Tokuda, Masaaki
AU - Matsui, Hideki
AU - Janjua, Najma A.
AU - Suwaki, Hiroshi
AU - Okada, Yasushi
AU - Negi, Tetsuro
AU - Murakami, Tetuhide H.
AU - Hatase, Osamu
N1 - Funding Information:
This work was supported by a Grant-in Aid for Scientific Research (C) from the Ministry of Education, Science and Culture of Japan.
PY - 1993/12/10
Y1 - 1993/12/10
N2 - The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like, peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 μg/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 μg.kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.
AB - The inhibitory effects of ceruletide (CLT), a cholecystokinin-8 (CCK)-like, peptide, were investigated in the epileptogenesis in the amygdaloid kindled rats. Lower doses of CLT (20-80 μg/kg) inhibited the progression of kindling process. After acquiring C5 stage, a higher dose (160 μg.kg) was required to suppress the seizure susceptibility. These results, in light of several previous studies showing no serious side effects, suggest that CLT might be useful as an anti-epileptogenic agent for clinical usage.
KW - CCK
KW - Ceruletide
KW - Epilepsy
KW - Kindling
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U2 - 10.1016/0006-8993(93)90678-G
DO - 10.1016/0006-8993(93)90678-G
M3 - Article
C2 - 8118705
AN - SCOPUS:0027386167
SN - 0006-8993
VL - 630
SP - 353
EP - 356
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -