抄録
In this study, Mg2+-containing hydroxyapatite (MgHAp) and chitosan (CS) composite particles (MgHAp/CS) with different CS contents were synthesized, and the relationship between CS content and adsorption of negatively charged protein (bovine serum albumin), was investigated. The CS content in the particles ranged from 18–42 wt %. Specific surface area results indicated that higher CS content could lead to CS aggregation on and between MgHAp particles. The saturation adsorption of bovine serum albumin on the MgHAp/CS particles ranged from 1.48 to 3.64 mg/m2. The particles with 42 wt % CS content exhibited the highest saturation adsorption amount among the particles. Additionally, protein adsorption tended to increase with higher CS content, probably because more positively charged CS (–NH3+) on the particle surface facilitates electrostatic interactions with negatively charged proteins. This suggests that positively charged CS in the particles can regulate the amount of protein adsorbed.
本文言語 | English |
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ページ(範囲) | 628-632 |
ページ数 | 5 |
ジャーナル | Journal of the Ceramic Society of Japan |
巻 | 132 |
号 | 11 |
DOI | |
出版ステータス | Published - 11月 2024 |
ASJC Scopus subject areas
- セラミックおよび複合材料
- 化学一般
- 凝縮系物理学
- 材料化学