Effect of oestradiol replacement in ovariectomized chickens on pituitary LH concentrations and concentrations of mRNAs encoding LH β and α subunits

O. Terada, K. Shimada, N. Saito

研究成果査読

13 被引用数 (Scopus)

抄録

Plasma concentrations of oestradiol and LH and steady-state pituitary concentrations of the mRNAs encoding the LH β and α subunits in the gland were measured at intervals of 1 month for 5 months in female chickens. In addition, feedback regulation by oestradiol of concentrations of mRNAs encoding these LH subunits was studied in ovariectomized young (3-week-old) and adult hens. Concentrations of the mRNAs encoding the LH β and α subunits increased significantly before sexual maturity and the changes were highly correlated with increases in plasma and pituitary concentrations of LH. Ovariectomy significantly reduced circulating plasma concentrations of oestradiol but increased pituitary concentrations of mRNAs encoding LH β and α subunits and pituitary and plasma concentrations of LH in adult laying hens. In addition, in 3-week-old chickens, ovariectomy induced an increase in plasma and pituitary gland concentrations of LH. This ovariectomy-induced mRNA expression and tissue and plasma increases of LH were prevented by oestradiol replacement. These data suggest that a negative feedback mechanism by ovarian oestradiol inhibits LH release from the pituitary and pituitary LH biosynthesis in chickens.

本文言語English
ページ(範囲)59-64
ページ数6
ジャーナルJournal of Reproduction and Fertility
111
1
出版ステータスPublished - 9月 1997
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 胎生学
  • 分子生物学
  • 産婦人科学
  • 発生生物学

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