Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats

Shin Tokunaga, Yasuhiro Takeda, Tsuyoshi Niimoto, Norihisa Nishida, Toshihiro Kubo, Tohru Ohno, Youichi Matsuura, Yuzo Kawahara, Kazuaki Shinomiya, Chiaki Kamei

研究成果査読

26 被引用数 (Scopus)

抄録

In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.

本文言語English
ページ(範囲)363-366
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
30
2
DOI
出版ステータスPublished - 2月 2007

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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