Effects of Δ8-tetrahydrocannabinol and its active metabolites on metabolic disposition of pentobarbital in the mouse

K. Watanabe, S. Narimatsu, M. Itoh

研究成果査読

抄録

Effects of Δ8-tetrahydrocannabinol (Δ8-THC), 11-hydroxy-Δ8-THC and 11-oxo-Δ8-THC on metabolic disposition of pentobarbital in plasma, brain and liver of mice were studied. By pretreatments of mice with these cannabinoids (5 mg/kg, i.v.), the tissue concentrations of pentobarbital at 30 min after the i.p. injection (40 mg/kg) were not changed as compared with the control, although elimination of pentobarbital from the tissue in mice pretreated with cannabinoids were slower than those of the control mice. Pentobarbital concentration in brain at the time of awakening was 0.149 (control), 0.102 (Δ6-THC), 0.073 (11-hydroxy-Δ8-THC) or 0.064 μmoles/g (11-oxo-Δ8-THC). The result suggests that 11-hydroxy-Δ8-THC and 11-oxo-Δ8-THC possess a greater activity to the central nervous sytem than Δ8-THC.

本文言語English
ページ(範囲)203-211
ページ数9
ジャーナルResearch Communications in Substances of Abuse
2
3
出版ステータスPublished - 1981
外部発表はい

ASJC Scopus subject areas

  • 医学(その他)

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