Effects of activation of hedgehog signaling on patterning, growth, and differentiation in Xenopus froglet limb regeneration

Nayuta Yakushiji, Makoto Suzuki, Akira Satoh, Hiroyuki Ide, Koji Tamura

研究成果査読

28 被引用数 (Scopus)

抄録

Regenerating limbs of urodele amphibians and Xenopus tadpole are reconstructed along proximal-distal, anterior-posterior (AP), and dorsal-ventral axes. In contrast, a regenerated limb of the Xenopus froglet does not have digits, and only a simple cartilaginous structure referred to as a "spike" is formed. This suggests that repatterning along the AP axis is absent in the froglet blastema. Previous studies have shown that Shh and its target genes are not expressed in the froglet blastema. In this study, we activated Hedgehog signaling in the froglet blastema and found that target genes of Shh were inducible in the mesenchyme of limb blastema. Furthermore, we found that activation of the signaling had effects on blastema cell proliferation and chondrogenesis and resulted in the formation of multiple cartilaginous structures. These findings indicate that activation of signaling that is absent in the froglet blastema is effective for improvement of limb regeneration ability in the Xenopus froglet.

本文言語English
ページ(範囲)1887-1896
ページ数10
ジャーナルDevelopmental Dynamics
238
8
DOI
出版ステータスPublished - 8月 2008
外部発表はい

ASJC Scopus subject areas

  • 発生生物学

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