Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats

Kozo Yamaji, Masamitsu Kawanami, Atsushi Matsumoto, Tomoomi Odajima, Yoshihiro Nishitani, Kensuke Iwasaka, Keiko Yoshimitsu, Masahiro Yoshiyama

研究成果査読

14 被引用数 (Scopus)

抄録

This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

本文言語English
ページ(範囲)481-486
ページ数6
ジャーナルDental materials journal
26
4
DOI
出版ステータスPublished - 7月 2007

ASJC Scopus subject areas

  • セラミックおよび複合材料
  • 歯学一般

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