Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly

Junko Goto; Fumio Otsuka; Kenichi Inagaki; Naoko Yamauchi; Jiro Suzuki; Tomoko Miyoshi; Toshio Ogura; Yasuhiko Kamada; Hirofumi Makino

doi:10.1507/endocrj.K08E-215

Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly

Junko Goto, Fumio Otsuka, Kenichi Inagaki, Naoko Yamauchi, Jiro Suzuki, Tomoko Miyoshi, Toshio Ogura, Yasuhiko Kamada, Hirofumi Makino

研究成果 › 査読

5 被引用数 (Scopus)

抄録

We report a rare case of polycystic ovary syndrome (PCOS) complicated with acromegaly due to a growth hormone (GH)-producing pituitary adenoma. Complete removal of the pituitary adenoma successfully reduced circulating levels of GH and insulin-like growth factor (IGF)-l, which, in turn, resulted in the amelioration of gonadal dysfunction, hyperandrogenism, lutenizing hormone hypersecretion, and severe insulin resistance. This clinical complication suggests that activation of systemic GH-IGF-1 axis is potentially involved in the development of PCOS.

本文言語	English
ページ（範囲）	157-160
ページ数	4
ジャーナル	Endocrine journal
巻	56
号	1
DOI	https://doi.org/10.1507/endocrj.K08E-215
出版ステータス	Published - 2009

ASJC Scopus subject areas

内分泌学、糖尿病および代謝内科学
内分泌学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1507/endocrj.K08E-215

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AU - Goto, Junko

AU - Otsuka, Fumio

AU - Inagaki, Kenichi

AU - Yamauchi, Naoko

AU - Suzuki, Jiro

AU - Miyoshi, Tomoko

AU - Ogura, Toshio

AU - Kamada, Yasuhiko

AU - Makino, Hirofumi

PY - 2009

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AB - We report a rare case of polycystic ovary syndrome (PCOS) complicated with acromegaly due to a growth hormone (GH)-producing pituitary adenoma. Complete removal of the pituitary adenoma successfully reduced circulating levels of GH and insulin-like growth factor (IGF)-l, which, in turn, resulted in the amelioration of gonadal dysfunction, hyperandrogenism, lutenizing hormone hypersecretion, and severe insulin resistance. This clinical complication suggests that activation of systemic GH-IGF-1 axis is potentially involved in the development of PCOS.

KW - Acromegaly

KW - Growth hormone

KW - Hyperglycemia

KW - Insulin-like growth factor-1

KW - Polycystic ovary syndrome

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Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly

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ASJC Scopus subject areas

UN SDG

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