抄録
The use of rhBMP-2 to induce ectopic bone formation requires a carrier. Type I atelocollagen, a biomaterial with a porous structure, excellent operational features and biocompatibility, is known to be an effective carrier for rhBMP-2. However, conventionally used lyophilized rhBMP-2/collagen mixture does not necessarily give adequate bone induction effect. In the present study, we examined the effect of immobilizing rhBMP-2 to type I atelocollagen on the cellular activity of ST2 cells. The following results were obtained: (1) rhBMP-2 was effectively immobilized to succinylated type I atelocollagen, indicating the usefulness of succinylated type I atelocollagen in immobilization. (2) Studies of alkaline phosphatase activity confirmed the effectiveness of rhBMP-2 immobilized on succinylated in augmenting cellular activity.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 126-127 |
| ページ数 | 2 |
| ジャーナル | Journal of Hard Tissue Biology |
| 巻 | 14 |
| 号 | 2 |
| DOI | |
| 出版ステータス | Published - 2005 |
ASJC Scopus subject areas
- 医学（その他）
- 生化学
- 生体材料
- 整形外科およびスポーツ医学
- 歯科学（全般）
- 細胞生物学