TY - JOUR
T1 - Effects of Lecithinized SOD on Contusion Injury in Rats
AU - Yunoki, M.
AU - Noguchi, Y.
AU - Nishio, S.
AU - Ono, Y.
AU - Kawauchi, M.
AU - Asai, S.
AU - Ohmoto, T.
AU - Asanuma, M.
AU - Ogawa, N.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - To analyze the effect of lecithinized superoxide dismutase (SOD) on superoxide accumulation after traumatic injury, the expression of Cu,Zn-SOD mRNA was examined after contusion in rat using Northern blotting. As determined by specific gravity, lecithinized SOD decreased brain edema. The expression of Cu,Zn-SOD mRNA increased at the core, peripheral and contralateral hemisphere of injury. These increases were then suppressed by lecithinized SOD. Our results support the hypothesis that superoxide may play an important role in edema formation after contusion, and that lecithinized SOD appears to prevent brain edema through a protective effect against superoxide injury.
AB - To analyze the effect of lecithinized superoxide dismutase (SOD) on superoxide accumulation after traumatic injury, the expression of Cu,Zn-SOD mRNA was examined after contusion in rat using Northern blotting. As determined by specific gravity, lecithinized SOD decreased brain edema. The expression of Cu,Zn-SOD mRNA increased at the core, peripheral and contralateral hemisphere of injury. These increases were then suppressed by lecithinized SOD. Our results support the hypothesis that superoxide may play an important role in edema formation after contusion, and that lecithinized SOD appears to prevent brain edema through a protective effect against superoxide injury.
KW - Contusion
KW - Free radicals
KW - Superoxide dismutase (SOD)
UR - http://www.scopus.com/inward/record.url?scp=1842639149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842639149&partnerID=8YFLogxK
U2 - 10.1007/978-3-7091-6837-0_56
DO - 10.1007/978-3-7091-6837-0_56
M3 - Article
C2 - 9416316
AN - SCOPUS:1842639149
SN - 0065-1419
VL - 1997
SP - 182
EP - 184
JO - Acta Neurochirurgica, Supplement
JF - Acta Neurochirurgica, Supplement
IS - 70
ER -