TY - JOUR
T1 - Effects of salicylic acid on mushroom tyrosinase and B16 melanoma cells
AU - Tamura, Sadaaki
AU - Nitoda, Teruhiko
AU - Kubo, Isao
N1 - Funding Information:
The authors are indebted to Ms. I. Hori for performing the cell-free tyrosinase assay at an earlier stage of the work. T. N. thanks Japan Society for the Promotion of Science for financial support during his study at UC, Berkeley.
PY - 2007
Y1 - 2007
N2 - Salicylic acid slightly inhibited the oxidation of L-3,4- dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.
AB - Salicylic acid slightly inhibited the oxidation of L-3,4- dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase noncompetitively without being oxidized. In contrast, 4-hydroxybenzoic acid did not inhibit this enzymatic oxidation if a longer reaction time was observed, although it suppressed the initial rate of the oxidation to a certain extent. Neither acid showed noticeable effects on cultured murine B16-F10 melanoma cells except weak cytotoxicity.
KW - B16-F10 melanoma cells
KW - Salicylic acid
KW - Tyrosinase
UR - http://www.scopus.com/inward/record.url?scp=34547434821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547434821&partnerID=8YFLogxK
U2 - 10.1515/znc-2007-3-412
DO - 10.1515/znc-2007-3-412
M3 - Article
C2 - 17542489
AN - SCOPUS:34547434821
SN - 0939-5075
VL - 62
SP - 227
EP - 233
JO - Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
JF - Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
IS - 3-4
ER -