抄録
We examined the effects of a histidine-deficient diet on brain histamine contents as well as on learning and memory using the eight-arm radial maze in rats. A significant decrease in histamine content in the hippocampus was observed after long-term feeding of rats with a histidine-deficient diet. At the same time, significant enhancement of the acquisition process in radial maze performance was also observed. Pyrilamine did not show a significant effect on radial maze performance in histidine-deficient rats. On the other hand, pyrilamine caused a significant spatial memory deficit in control rats. Scopolamine was effective in inhibiting spatial memory in both histidine-deficient and control rats. MK-801 caused spatial memory deficits more potently in histidine-deficient rats than in controls. Brain glycine contents showed a significant increase in the hippocampus in histidine-deficient rats. These results indicated that the spatial memory deficits induced by MK-801 in histidine-deficient rats are closely related to increased glycine levels and activation of NMDA receptors.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 2199-2208 |
| ページ数 | 10 |
| ジャーナル | Life Sciences |
| 巻 | 70 |
| 号 | 18 |
| DOI | |
| 出版ステータス | Published - 3月 22 2002 |
ASJC Scopus subject areas
- 生化学、遺伝学、分子生物学（全般）
- 薬理学、毒性学および薬学（全般）