Engineered bio-nanocapsules, the selective vector for drug delivery system

Dongwei Yu; Takayuki Fukuda; Tuoya; Shun'ichi Kuroda; Katsuyuki Tanizawa; Akihiko Kondo; Masakazu Ueda; Tadanori Yamada; Hiroko Tada; Masaharu Seno

doi:10.1080/15216540500484368

Engineered bio-nanocapsules, the selective vector for drug delivery system

Dongwei Yu, Takayuki Fukuda, Tuoya, Shun'ichi Kuroda, Katsuyuki Tanizawa, Akihiko Kondo, Masakazu Ueda, Tadanori Yamada, Hiroko Tada, Masaharu Seno

研究成果 › 査読

10 被引用数 (Scopus)

抄録

The bio-nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus-like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre-S1 region in N-terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.

本文言語	English
ページ（範囲）	1-6
ページ数	6
ジャーナル	IUBMB Life
巻	58
号	1
DOI	https://doi.org/10.1080/15216540500484368
出版ステータス	Published - 1月 2006

ASJC Scopus subject areas

生化学
分子生物学
遺伝学
臨床生化学
細胞生物学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1080/15216540500484368

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AU - Fukuda, Takayuki

AU - Tuoya,

AU - Kuroda, Shun'ichi

AU - Tanizawa, Katsuyuki

AU - Kondo, Akihiko

AU - Ueda, Masakazu

AU - Yamada, Tadanori

AU - Tada, Hiroko

AU - Seno, Masaharu

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KW - Specific infection

KW - Topology

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Engineered bio-nanocapsules, the selective vector for drug delivery system

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ASJC Scopus subject areas

UN SDG

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