Enhancement by blood transfusions of transplanted tumor growth in mice

研究成果査読

7 被引用数 (Scopus)

抄録

It has been demonstrated that the renal graft survival was prolonged after blood transfusion. The immunological action of blood transfusion in the host is not clear yet. The effect of blood transfusion on transplanted tumor growth in mice was examined. Using C3H/He (H-2k), AKR (H-2k), C57BL/6 (H-2b), and (C57BL/6xDBA/2)F1 (H-2b,d)mice, mutually different transfusion combinations were prepared. MH134 cells (hepatoma) originated from C3H/He mice or Lewis lung carcinoma cells originated from C57BL/6 mice were grafted beneath the back skin of mice on the second week after transfusion, and size of the tumor was measured. The results showed that 1) blood transfusion among mice with the same H-2 systems had no enhancing effect on grafted tumor growth, 2) blood transfusion among mice with different H-2 systems markedly enhanced the tumor growth, although different in degrees, 3) In the experiments of component transfusions, transfusion of lymphoid cells also enhanced the tumor growth, but not erythrocytes. The results of these experiments clearly showed the differential effects of allogeneic or syngeneic blood transfusion on transplanted tumor growth in mice.

本文言語English
ページ(範囲)513-520
ページ数8
ジャーナルNippon Geka Gakkai zasshi
85
6
出版ステータスPublished - 6月 1984
外部発表はい

ASJC Scopus subject areas

  • 医学一般

フィンガープリント

「Enhancement by blood transfusions of transplanted tumor growth in mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル