Exposure of mouse to high gravitation forces induces long-term potentiation in the hippocampus

Masamitsu Ishii, Kazuhito Tomizawa, Masayuki Matsushita, Hideki Matsui

研究成果査読

6 被引用数 (Scopus)

抄録

The central nervous system is highly plastic and has been shown to undergo both transient and chronic adaptive changes in response to environmental influences. The purpose of this study was to investigate the effect of hypergravic field on long-term potentiation (LTP) in the mouse hippocampus. Exposure of mice to 4G fields for 48 h had no effect on input-output coupling during extracellular stimulation of Schaffer collaterals and paired pulse facilitation, suggesting that the hypergravic exposure had no detrimental effect on basal neurotransmission in the hippocampus. However, the exposure to 4G fields for 48 h significantly induced LTP compared with the control mouse hippocampus. In contrast, no significant changes of late-phase LTP (L-LTP) were found in the hippocampi of mice exposed to the hypergravic field. Exposure of mice to 4G fields for 48 h enhanced AMPA receptor phosphorylation but not cyclic AMP-responsive element binding protein (CREB) phosphorylation. These results suggest that exposure to hyperdynamic fields influences the synaptic plasticity in the hippocampus.

本文言語English
ページ(範囲)143-149
ページ数7
ジャーナルActa medica Okayama
58
3
出版ステータスPublished - 6月 2004
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般

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