Expression of Osteonectin in Articular Cartilage of Osteoarthritic Knees

Yoshifumi Nanba, Keiichiro Nishida, Takeshi Yoshikawa, Toru Sato, Hajime Inoue, Yoshinori Kuboki


14 被引用数 (Scopus)


The expression of osteonectin (ON) in osteoarthritic articular cartilage was investigated by enzyme immunohistochemistry and colloidal gold immunoelectron microscopy. A total of 96 specimens from 9 knees of 8 patients with osteoarthritis (OA) were examined. In OA cartilage, ON-positive cells varied in distribution and were not seen in all the specimens obtained from the same patient. However, in over half of the specimens (56 of 96), especially in the specimens of Mankin's grades from 4 to 9, which corresponds to relatively early stages of OA, ON was expressed in the cartilage above the calcified layer. On the other hand, ON was detected only in the calcified layer below the tidemark in normal articular cartilage. In addition, colloidal gold immunoelectron microscopy revealed ON in chondrocytes and matrix vesicles (MVs). These findings suggest that ON acts through MVs in the early stages of OA as a significant pathogenetic factor involved in intracartilage calcification, which is known to have a close relationship to the progression of OA.

ジャーナルActa medica Okayama
出版ステータスPublished - 10月 1997

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)


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