TY - JOUR
T1 - Functional improvement by electro-acupuncture after transient middle cerebral artery occlusion in rats
AU - Wang, S. J.
AU - Omori, N.
AU - Li, F.
AU - Jin, G.
AU - Hamakawa, Y.
AU - Sato, K.
AU - Nagano, I.
AU - Shoji, M.
AU - Abe, K.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Functional recovery by the application of electro-acupuncture (EA) on different acupoints was investigated using a transient middle cerebral artery occlusion (MCAO) model in rat. Acupoints were Baihui (D20) plus Renzhong (D26) (MCAO+ D group), and Hanyan (G4), Xuanlu (G5), Xuanli (G6), plus Qubin (G7) (MCAP+ G group). Animals with EA treatment showed significant functional improvements from 12 days after the reperfusion against those without EA treatment. Among EA treated groups, MCAO+ G showed a more significant recovery than MCAO+ D. Infarct volume revealed the significant reduction in the EA treated groups especially in MCAO+ G at 30 days. Immunohistochemical study showed a remarkable induction of vascular endothelial growth factor (VEGF) in astrocytes of the peri-infarct area at 30 days, more in EA treated groups than in groups treated with MCAO alone. These results suggest that the acupoints applied in this study are effective for the functional recovery, and an enhanced expression of VEGF may play a certain role in recovery process after stroke.
AB - Functional recovery by the application of electro-acupuncture (EA) on different acupoints was investigated using a transient middle cerebral artery occlusion (MCAO) model in rat. Acupoints were Baihui (D20) plus Renzhong (D26) (MCAO+ D group), and Hanyan (G4), Xuanlu (G5), Xuanli (G6), plus Qubin (G7) (MCAP+ G group). Animals with EA treatment showed significant functional improvements from 12 days after the reperfusion against those without EA treatment. Among EA treated groups, MCAO+ G showed a more significant recovery than MCAO+ D. Infarct volume revealed the significant reduction in the EA treated groups especially in MCAO+ G at 30 days. Immunohistochemical study showed a remarkable induction of vascular endothelial growth factor (VEGF) in astrocytes of the peri-infarct area at 30 days, more in EA treated groups than in groups treated with MCAO alone. These results suggest that the acupoints applied in this study are effective for the functional recovery, and an enhanced expression of VEGF may play a certain role in recovery process after stroke.
KW - Electro-acupuncture
KW - Foot fault testing
KW - Neurologic examination
KW - Parallel bar testing
KW - Transient middle cerebral artery occlusion
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=0038503404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038503404&partnerID=8YFLogxK
U2 - 10.1179/016164103101201751
DO - 10.1179/016164103101201751
M3 - Article
C2 - 12866201
AN - SCOPUS:0038503404
SN - 0161-6412
VL - 25
SP - 516
EP - 521
JO - Neurological Research
JF - Neurological Research
IS - 5
ER -