G-CSF enhances stem cell proliferation in rat hippocampus after transient middle cerebral artery occlusion

Yoshihide Sehara, Takeshi Hayashi, Kentaro Deguchi, Hanzhe Zhang, Atsushi Tsuchiya, Toru Yamashita, Violeta Lukic, Makiko Nagai, Tatsushi Kamiya, Koji Abe

研究成果査読

13 被引用数 (Scopus)

抄録

Granulocyte colony-stimulating factor (G-CSF) enhances the survival and stimulates the proliferation of neutrophil progenitors. Recently, the neurogenerative effect of G-CSF has been intensely investigated. In this study, we explored the possibility that G-CSF enhanced the cell proliferation in the rat dentate gyrus (DG) after focal cerebral ischemia, using a rat transient middle cerebral artery occlusion (tMCAO) model. At 7 days after tMCAO, the number of 5-bromodeoxyuridine (BrdU)-positive cells in the G-CSF-treated group was significantly increased compared with that in the vehicle-treated group in the ipsilateral SGZ (16.6 ± 5.5/mm2 in the vehicle-treated group versus 33.0 ± 7.2/mm2 in the G-CSF-treated group, **p < 0.01) and in the ipsilateral GCL (14.2 ± 2.8/mm2 in the vehicle-treated group versus 21.0 ± 3.8/mm2 in the G-CSF-treated group, *p < 0.05). This result showed the possibility of a neurogenerative role of G-CSF after tMCAO in rats.

本文言語English
ページ(範囲)248-252
ページ数5
ジャーナルNeuroscience Letters
418
3
DOI
出版ステータスPublished - 5月 18 2007

ASJC Scopus subject areas

  • 神経科学一般

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