GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes

Dequina A. Nicholas, Vashti S. Knight, Karen J. Tonsfeldt, Tomohiro Terasaka, Olivia Molinar-Inglis, Shannon B.Z. Stephens, Jo Ann Trejo, Alexander S. Kauffman, Pamela L. Mellon, Mark A. Lawson


2 被引用数 (Scopus)


The mechanisms mediating suppression of reproduction in response to decreased nutrient availability remain undefined, with studies suggesting regulation occurs within the hypothalamus, pituitary, or gonads. By manipulating glucose utilization and GLUT1 expression in a pituitary gonadotrope cell model and in primary gonadotropes, we show GLUT1-dependent stimulation of glycolysis, but not mitochondrial respiration, by the reproductive neuropeptide GnRH. GnRH stimulation increases gonadotrope GLUT1 expression and translocation to the extracellular membrane. Maximal secretion of the gonadotropin Luteinizing Hormone is supported by GLUT1 expression and activity, and GnRH-induced glycolysis is recapitulated in primary gonadotropes. GLUT1 expression increases in vivo during the GnRH-induced ovulatory LH surge and correlates with GnRHR. We conclude that the gonadotropes of the anterior pituitary sense glucose availability and integrate this status with input from the hypothalamus via GnRH receptor signaling to regulate reproductive hormone synthesis and secretion.

ジャーナルScientific reports
出版ステータスPublished - 12月 1 2020

ASJC Scopus subject areas

  • 一般


「GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。