Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23

Hiroyuki Nomoto, Toshitaka Oohashi, Satoshi Hirakawa, Yasuyoshi Ueki, Hiroshi Ohtsuki, Yoshifumi Ninomiya

研究成果査読

7 被引用数 (Scopus)

抄録

We herein determined by fluorescence in situ hybridization the chromosomal localization of 2 human genes, BRAL1 and BCAN, both of which belong to the link-module superfamily, i.e. to the same band of chromosome 1q21-23. Further analysis of the genomic organization of BRAL1 and BCAN revealed that the BRAL1 gene was located 20-kb upstream of the BCAN start site. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the BCAN gene. High heterozygosity (0.79) makes this polymorphism a useful marker in the study of genetic disorders. Knowledge of the structure of the genes and the marker provides essential information for further analysis of the gene locus at chromosome 1q21-23.

本文言語English
ページ(範囲)25-29
ページ数5
ジャーナルActa medica Okayama
56
1
出版ステータスPublished - 2002

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般

フィンガープリント

「Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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