Hydroa vacciniforme is associated with increased numbers of epstein-barr virus-infected γδT cells

Yoji Hirai, Takenobu Yamamoto, Hiroshi Kimura, Yoshinori Ito, Kazuhide Tsuji, Tomoko Miyake, Shin Morizane, Daisuke Suzuki, Kazuyasu Fujii, Keiji Iwatsuki


43 被引用数 (Scopus)


Hydroa vacciniforme (HV) is a rare photosensitivity disorder of childhood associated with Epstein-Barr virus (EBV)+ T-cell infiltration. We have summarized clinical manifestations of HV, and analyzed EBV+ T-cell subsets as well as EBV DNA load in lymphocyte fractions, in comparison with hypersensitivity to mosquito bites (HMB), an EBV-associated T/natural killer (NK) lymphoproliferative disorder. We found that 31 of 33 (93.9%) HV lesions were composed of EBV+ T cells and reactive EBV- cytotoxic T cells, without significant CD56+ cell infiltration, whereas many CD56+ cells were present in 8 of 9 (88.9%) HMB lesions. Of 13 (20.6%) HMB patients with or without HV, 12 (92.3%) showed increased percentages (>32%) of NK cells in the peripheral blood, whereas in the 16 patients with HV alone, 14 (87.5%) showed no increase. Of the 11 HV patients, 10 (90.9%) had increased percentages (>5%) of circulating γδT cells, with a mean value of 15.7 ± 2.9%, and the γδT-cell fractions contained larger amounts of EBV DNA than non-γδT-cell fractions. A triple-labeling method revealed that all three HV patients examined had increased percentages of EBER+, T-cell receptor (TCR)γδ+ , and TCRαΒ- cells. Our observations indicate that HV is associated with increased numbers of EBV + γδT cells, whereas HMB is associated with EBV + NK cells.

ジャーナルJournal of Investigative Dermatology
出版ステータスPublished - 5月 2012

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 皮膚病学
  • 細胞生物学


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