Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Takanori Nakamura; Tomomi Noguchi; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.55.651

Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

Takanori Nakamura
, Tomomi Noguchi
, Hiroyuki Miyachi
, Yuichi Hashimoto

研究成果 › 査読

15 被引用数 (Scopus)

抄録

Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

本文言語	English
ページ（範囲）	651-654
ページ数	4
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	55
号	4
DOI	https://doi.org/10.1248/cpb.55.651
出版ステータス	Published - 4月 2007
外部発表	はい

ASJC Scopus subject areas

化学一般
創薬

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10.1248/cpb.55.651

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abstract = "Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.",

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AU - Miyachi, Hiroyuki

AU - Hashimoto, Yuichi

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Y1 - 2007/4

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AB - Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

KW - Hydrolyzed thalidomide

KW - Metabolite

KW - Thalidomide

KW - Tumor necrosis factor (TNF)-α modulator

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Hydrolyzed metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity

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