Hydroxy-carbonate apatite: Synthesis, blood compatibility and adsorption of specific pathogenic proteins

Satoshi Hayakawa; Yuko Kusudo; Shinji Takemoto; Kanji Tsuru; Akiyoshi Osaka; Seisuke Takashima

Hydroxy-carbonate apatite: Synthesis, blood compatibility and adsorption of specific pathogenic proteins

Satoshi Hayakawa, Yuko Kusudo, Shinji Takemoto, Kanji Tsuru, Akiyoshi Osaka, Seisuke Takashima

研究成果 › 査読

抄録

Hydroxy-carbonate apatite (CAp) compositions containing carbonate ions from 0 to 10.9 wt% were synthesized by a wet chemical method. Infrared analysis revealed that carbonate ions were substituted both PO₄^3- and OH^- sites. The introduction of CO₃^2- ion into the hydroxyapatite lattice led to an increase in specific surface area and surface charge density. Blood clotting properties were not affected by the contact with CAp samples. The adsorption behavior of proteins was investigated by contacting CAp with model saline containing bovine serum albumin (BSA) and β₂-microglobulin (β₂-MG). The selectivity against β₂-MG increased with increase in the amount of carbonate ions. As surface charge density increased with increase in the amount of carbonate ions, surface charge density played an important role in selective adsorption of β₂-MG, but not a sole factor.

本文言語	English
ページ	111-119
ページ数	9
出版ステータス	Published - 12月 1 2003
イベント	Bioceramics: Materials and Applications IV, Proceedings - Nashville, TN 継続期間: 4月 27 2003 → 4月 30 2003

Conference

Conference	Bioceramics: Materials and Applications IV, Proceedings
国/地域	United States
City	Nashville, TN
Period	4/27/03 → 4/30/03

ASJC Scopus subject areas

セラミックおよび複合材料
材料化学

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引用スタイル

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abstract = "Hydroxy-carbonate apatite (CAp) compositions containing carbonate ions from 0 to 10.9 wt% were synthesized by a wet chemical method. Infrared analysis revealed that carbonate ions were substituted both PO43- and OH- sites. The introduction of CO32- ion into the hydroxyapatite lattice led to an increase in specific surface area and surface charge density. Blood clotting properties were not affected by the contact with CAp samples. The adsorption behavior of proteins was investigated by contacting CAp with model saline containing bovine serum albumin (BSA) and β2-microglobulin (β2-MG). The selectivity against β2-MG increased with increase in the amount of carbonate ions. As surface charge density increased with increase in the amount of carbonate ions, surface charge density played an important role in selective adsorption of β2-MG, but not a sole factor.",

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AU - Hayakawa, Satoshi

AU - Kusudo, Yuko

AU - Takemoto, Shinji

AU - Tsuru, Kanji

AU - Osaka, Akiyoshi

AU - Takashima, Seisuke

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AB - Hydroxy-carbonate apatite (CAp) compositions containing carbonate ions from 0 to 10.9 wt% were synthesized by a wet chemical method. Infrared analysis revealed that carbonate ions were substituted both PO43- and OH- sites. The introduction of CO32- ion into the hydroxyapatite lattice led to an increase in specific surface area and surface charge density. Blood clotting properties were not affected by the contact with CAp samples. The adsorption behavior of proteins was investigated by contacting CAp with model saline containing bovine serum albumin (BSA) and β2-microglobulin (β2-MG). The selectivity against β2-MG increased with increase in the amount of carbonate ions. As surface charge density increased with increase in the amount of carbonate ions, surface charge density played an important role in selective adsorption of β2-MG, but not a sole factor.

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Hydroxy-carbonate apatite: Synthesis, blood compatibility and adsorption of specific pathogenic proteins

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Conference

ASJC Scopus subject areas

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