Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen

Lee F. Peng, Suk Kim Sun, Sirinya Matchacheep, Xiaoguang Lei, Shun Su, Wenyu Lin, Weerawat Runguphan, Won Hyeok Choe, Naoya Sakamoto, Masanori Ikeda, Nobuyuki Kato, Aaron B. Beeler, John A. Porco, Stuart L. Schreiber, Raymond T. Chung

研究成果査読

15 被引用数 (Scopus)

抄録

Using our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 μM). We then synthesized an analog of these compounds with optimized activity.

本文言語English
ページ(範囲)3756-3759
ページ数4
ジャーナルAntimicrobial Agents and Chemotherapy
51
10
DOI
出版ステータスPublished - 10月 2007
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)
  • 感染症

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