@article{2b537f21fcbe4e53a9814a8459b32aa8,
title = "Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma",
abstract = "Background: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. Methods: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. Results: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P =.008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P =.02). Conclusion: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.",
keywords = "budding, early tongue cancer, lymph node metastasis, multivariate analysis, prognostic factor",
author = "Yasuhiro Ebihara and Saori Yoshida and Mitsuhiko Nakahira and Yasunao Kogashiwa and Yuichiro Enoki and Kiyomi Kuba and Hitoshi Inoue and Kazuhiko Minami and Masanori Yasuda and Masashi Sugasawa",
note = "Funding Information: The authors are grateful to Koichi Kamata for substantial contributions to technical support of immunohistochemical staining. This study was supported by a Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research C (Grant No. 17K11404). Funding Information: JSPS Grant-in-Aid for Scientific Research C, Grant/Award Number: 17K11404; Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research C, Grant/Award Number: 17K11404 Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = jun,
doi = "10.1002/hed.25614",
language = "English",
volume = "41",
pages = "1809--1815",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "6",
}
