In Vitro Cytocompatibility of Osteoblastic Cells Cultured on Chitosan-Organosiloxane Hybrid Membrane

Y. Shirosaki; K. Tsuru; S. Hayakawa; A. Osaka; M. A. Lopes; J. D. Santos; M. H. Fernandes

In Vitro Cytocompatibility of Osteoblastic Cells Cultured on Chitosan-Organosiloxane Hybrid Membrane

Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka, M. A. Lopes, J. D. Santos, M. H. Fernandes

研究成果 › 査読

抄録

Chitosan-silicate hybrids were synthesized using γ-glycidoxypropyltrimethoxysilane (GPSM) as the agent to cross-link the chitosan chains. Fourier-transform infrared (PT-IR) spectroscopy was used to analyze the structures of the hybrids. The swelling ability and the cytocompatibility of the hybrids were investigated as a function of the GPSM concentration. The swelling of the hybrids was suppressed by addition of GPSM. MG63 human osteoblastic cells were cultured on the hybrids. The adhesion and proliferation of the MG63 cells cultured on the chitosan-GPSM hybrid surface were improved comparing to that on chitosan membrane, regardless the GPSM concentration.

本文言語	English
ページ（範囲）	857-860
ページ数	4
ジャーナル	Key Engineering Materials
巻	254-256
出版ステータス	Published - 2004
イベント	The Annual Meeting of the International Society for Ceramics in Medicine - Porto 継続期間: 11月 6 2003 → 11月 9 2003

ASJC Scopus subject areas

材料科学一般
材料力学
機械工学

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title = "In Vitro Cytocompatibility of Osteoblastic Cells Cultured on Chitosan-Organosiloxane Hybrid Membrane",

abstract = "Chitosan-silicate hybrids were synthesized using γ-glycidoxypropyltrimethoxysilane (GPSM) as the agent to cross-link the chitosan chains. Fourier-transform infrared (PT-IR) spectroscopy was used to analyze the structures of the hybrids. The swelling ability and the cytocompatibility of the hybrids were investigated as a function of the GPSM concentration. The swelling of the hybrids was suppressed by addition of GPSM. MG63 human osteoblastic cells were cultured on the hybrids. The adhesion and proliferation of the MG63 cells cultured on the chitosan-GPSM hybrid surface were improved comparing to that on chitosan membrane, regardless the GPSM concentration.",

keywords = "Chitosan, Chitosan-inorganic hybrid, Cytocompatibility, Osteoblastic cell (MG63), γ-glycidoxypropyltrimethoxysilane (GPSM)",

author = "Y. Shirosaki and K. Tsuru and S. Hayakawa and A. Osaka and Lopes, {M. A.} and Santos, {J. D.} and Fernandes, {M. H.}",

year = "2004",

language = "English",

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pages = "857--860",

journal = "Key Engineering Materials",

issn = "1013-9826",

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note = "The Annual Meeting of the International Society for Ceramics in Medicine ; Conference date: 06-11-2003 Through 09-11-2003",

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TY - JOUR

T1 - In Vitro Cytocompatibility of Osteoblastic Cells Cultured on Chitosan-Organosiloxane Hybrid Membrane

AU - Shirosaki, Y.

AU - Tsuru, K.

AU - Hayakawa, S.

AU - Osaka, A.

AU - Lopes, M. A.

AU - Santos, J. D.

AU - Fernandes, M. H.

PY - 2004

Y1 - 2004

N2 - Chitosan-silicate hybrids were synthesized using γ-glycidoxypropyltrimethoxysilane (GPSM) as the agent to cross-link the chitosan chains. Fourier-transform infrared (PT-IR) spectroscopy was used to analyze the structures of the hybrids. The swelling ability and the cytocompatibility of the hybrids were investigated as a function of the GPSM concentration. The swelling of the hybrids was suppressed by addition of GPSM. MG63 human osteoblastic cells were cultured on the hybrids. The adhesion and proliferation of the MG63 cells cultured on the chitosan-GPSM hybrid surface were improved comparing to that on chitosan membrane, regardless the GPSM concentration.

AB - Chitosan-silicate hybrids were synthesized using γ-glycidoxypropyltrimethoxysilane (GPSM) as the agent to cross-link the chitosan chains. Fourier-transform infrared (PT-IR) spectroscopy was used to analyze the structures of the hybrids. The swelling ability and the cytocompatibility of the hybrids were investigated as a function of the GPSM concentration. The swelling of the hybrids was suppressed by addition of GPSM. MG63 human osteoblastic cells were cultured on the hybrids. The adhesion and proliferation of the MG63 cells cultured on the chitosan-GPSM hybrid surface were improved comparing to that on chitosan membrane, regardless the GPSM concentration.

KW - Chitosan

KW - Chitosan-inorganic hybrid

KW - Cytocompatibility

KW - Osteoblastic cell (MG63)

KW - γ-glycidoxypropyltrimethoxysilane (GPSM)

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UR - http://www.scopus.com/inward/citedby.url?scp=0346885502&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0346885502

SN - 1013-9826

VL - 254-256

SP - 857

EP - 860

JO - Key Engineering Materials

JF - Key Engineering Materials

T2 - The Annual Meeting of the International Society for Ceramics in Medicine

Y2 - 6 November 2003 through 9 November 2003

ER -

In Vitro Cytocompatibility of Osteoblastic Cells Cultured on Chitosan-Organosiloxane Hybrid Membrane

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