Increased expression of COX-2 in the development of human lung cancers

Takashi Takahashi, Ken Ichi Kozaki, Yasushi Yatabe, Hiroyuki Achiwa, Toyoaki Hida


37 被引用数 (Scopus)


It is well accepted that an increase in the expression of cyclooxygenase-2 (COX-2), a key inducible enzyme involved in the production of prostaglandins and other eicosanoids, may play a significant role in carcinogenesis in addition to its well-known role in inflammatory reactions. Whereas previous studies were largely confined to colorectal tumorigenesis, we have shown that a significantly increased expression of COX-2 may also play a role in the development of lung cancer. COX-2 expression was found to be frequently elevated in lung cancer, especially in adenocarcinoma, and the proportion of lung cancer cells with marked COX-2 expression was much higher in lymph node metastases than in the corresponding primary tumors. It was also shown that early stage adenocarcinoma patients with increased COX-2 expression who were surgically treated had a shorter survival. Our studies, which used high- and low-metastatic human lung cancer cell sublines established in our laboratory, revealed an association between metastatic capabilities and COX-2 expression levels: COX-2-specific inhibitors could inhibit in vitro the invasion of the highly metastatic NCI-H460-LNM35 clone through Matrigel-containing basement membrane components as well as the spontaneous in vivo metastasis in SCID mice. Taken together, these findings suggest that an increase in COX-2 expression may be associated with the development of lung cancer and possibly with the acquisition of an invasive and metastatic phenotype.

ジャーナルJournal of Environmental Pathology, Toxicology and Oncology
出版ステータスPublished - 6月 29 2002

ASJC Scopus subject areas

  • 病理学および法医学
  • 毒物学
  • 健康、毒物学および変異誘発


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