Inhibition of placental ornithine decarboxylase by DL-α-difluoro-methyl ornithine causes fetal growth restriction in rat

Makoto Ishida, Yuji Hiramatsu, Hisashi Masuyama, Yasushi Mizutani, Takafumi Kudo

研究成果査読

22 被引用数 (Scopus)

抄録

The roles of polyamines in intrauterine growth restriction (IUGR) is studied. The DL-α-difluoromethyl ornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC) which is a rate limiting enzyme of polyamine synthesis was administrated to pregnant rats so that we obtained rat fetuses with IUGR. The changes of maternal nutrition, damage of the placenta, and the direct effect of DFMO on the fetus were examined in this IUGR model. Administration of DFMO did not induced changes of maternal nutrition except for triglyceride and the fetal metabolic state. But the placental weight, ODC activity, and DNA in the placenta were decreased significantly. The ODC activity in the total placenta decreased to less than 10% of that of the control. Depression of ODC activity in the placenta may be the major cause of IUGR induced by DFMO administration, and polyamines play important roles to carry pregnancy.

本文言語English
ページ(範囲)1395-1405
ページ数11
ジャーナルLife Sciences
70
12
DOI
出版ステータスPublished - 2月 8 2002

ASJC Scopus subject areas

  • 薬理学、毒性学および薬学一般
  • 生化学、遺伝学、分子生物学一般

フィンガープリント

「Inhibition of placental ornithine decarboxylase by DL-α-difluoro-methyl ornithine causes fetal growth restriction in rat」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル