Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice

Kiyonori Yamaoka, Takahiro Kataoka, Takaharu Nomura, Takehito Taguchi, Da Hong Wang, Shuji Mori, Katsumi Hanamoto, Shohei Kira

研究成果査読

30 被引用数 (Scopus)

抄録

The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.

本文言語English
ページ(範囲)89-95
ページ数7
ジャーナルJournal of radiation research
45
1
DOI
出版ステータスPublished - 3月 2004

ASJC Scopus subject areas

  • 放射線
  • 放射線学、核医学およびイメージング
  • 健康、毒物学および変異誘発

フィンガープリント

「Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル