Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats

Toshime Igarashi, Hiromasa Takashima, Michihito Takabe, Hiroshi Suzuki, Kazuo Ushida, Tomoko Kawamura, Mariko Matsumoto, Takako Iso, Shihori Tanabe, Kaoru Inoue, Atsushi Ono, Takashi Yamada, Akihiko Hirose

研究成果査読

5 被引用数 (Scopus)

抄録

Benzyl salicylate is used as a fragrance ingredient and an ultraviolet light absorber, but its toxicity is unknown. Therefore, toxicity tests and hazard classification were conducted for screening assessment under the Japanese Chemical Substances Control Law. Benzyl salicylate was found to be non-genotoxic in vitro based on the chromosomal aberration test using Chinese hamster lung cells. However, the combined repeated-dose and reproductive/developmental screening toxicity test, in which male and female rats were administered benzyl salicylate by gavage at 0, 30, 100, or 300 mg/kg/day for 42 and 41–46 days, respectively, from 14 days before mating until postnatal Day 4, showed that repeated doses had major effects on the thymus, liver, epididymis, and femur at 100 and/or 300 mg/kg/day. Furthermore, although benzyl salicylate had no effect on the estrus cycle, fertility, corpus lutea, or implantation rate, embryonic resorption, offspring mortality, and neural tube defects were observed at 300 mg/kg/day, and the offspring had lower body weights at 30 and 100 mg/kg/day, suggesting teratogenicity similar to other salicylates. Based on the developmental toxicity, this chemical was classified as hazard class 2, with a lowest observed adverse effect level (LOAEL) of 30 mg/kg/day and a D-value of 0.003 mg/kg/day.

本文言語English
ページ(範囲)105-117
ページ数13
ジャーナルRegulatory Toxicology and Pharmacology
100
DOI
出版ステータスPublished - 12月 2018

ASJC Scopus subject areas

  • 毒物学

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