Intraarterial Injection Chemotherapy Using Water-in-Oil (W/O) State Cisplatin-Lipiodol Emulsion (CPLEM) for Hepatocellular Carcinoma

For the treatment of hepatocellular carcinoma by intra-hepatic arterial injection, CDDP-Lipiodol emulsion (CPLEM) was prepared. CPLEM was in a water-in-oil state, and showed moderate retaining and releasing of CDDP. Clinically, 9 patients with advanced hepatocellular carcinoma underwent the transarterial chemo-embolization by CPLEM. Partial response was observed in 2 cases, and minor response 1 case. AFP decreased considerably, and side effects were slight. Serum platinum concentrations after administration were low. Deconvolution of the present data was demonstrated, and leakage of CDDP from liver was supposed to be gradual. In conclusion, CPLEM was considered to be useful for mild chemo-embolization in a treatment of hepatocellular carcinoma.