Intracellular distribution of a speech/language disorder associated FOXP2 mutant

Akifumi Mizutani, Ayumi Matsuzaki, Mariko Y. Momoi, Eriko Fujita, Yuko Tanabe, Takashi Momoi

    研究成果査読

    37 被引用数 (Scopus)

    抄録

    Although a mutation (R553H) in the forkhead box (FOX)P2 gene is associated with speech/language disorder, little is known about the function of FOXP2 or its relevance to this disorder. In the present study, we identify the forkhead nuclear localization domains that contribute to the cellular distribution of FOXP2. Nuclear localization of FOXP2 depended on two distally separated nuclear localization signals in the forkhead domain. A truncated version of FOXP2 lacking the leu-zip, Zn2+ finger, and forkhead domains that was observed in another patient with speech abnormalities demonstrated an aggregated cytoplasmic localization. Furthermore, FOXP2 (R553H) mainly exhibited a cytoplasmic localization despite retaining interactions with nuclear transport proteins (importin α and β). Interestingly, wild type FOXP2 promoted the transport of FOXP2 (R553H) into the nucleus. Mutant and wild type FOXP2 heterodimers in the nucleus or FOXP2 R553H in the cytoplasm may underlie the pathogenesis of the autosomal dominant speech/language disorder.

    本文言語English
    ページ(範囲)869-874
    ページ数6
    ジャーナルBiochemical and Biophysical Research Communications
    353
    4
    DOI
    出版ステータスPublished - 2月 23 2007

    ASJC Scopus subject areas

    • 生物理学
    • 生化学
    • 分子生物学
    • 細胞生物学

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