@article{ade05ac487904fa9ba54a8a778a27c0b,
title = "Lactobacillus-mediated RNA interference in nematode",
abstract = "We engineered Lactobacillus paracasei to produce a dsRNA that would trigger RNAi-induced silencing of an essential gene in the nematode Caenorhabditis elegans. The dsRNA-expressing L. paracasei can be used in experiments conducted on culture plates and may also be used as an orally administrable dsRNA carrier for humans and other mammals.",
keywords = "Caenorhabditis elegans, Lactic acid bacteria, Lactobacillus paracasei, Nematode, RNAi, dsRNA",
author = "Ai Kuwahara and Masashi Arita and Akira Kushiro and Yasuji Sakube and Masahiko Sisido and Takashi Ohtsuki",
note = "Funding Information: We thank Prof. H. Kagawa (Okayama University) for many helps in C. elegans experiments, Prof. Y. Kohara (National Institute of Genetics) for the cDNA clone, and Ms. S. Shibata for technical helps. The C. elegans strain the used for this work was provided by Caenorhabditis Genetics Center, which is funded by the NIH National Center for Research Resources (NCRR). This work was supported by Grant-in-Aid for Scientific Research on Priority Area “Cancer” from MEXT, Japan, to T. O. ",
year = "2010",
month = feb,
doi = "10.1016/j.jbiosc.2009.08.002",
language = "English",
volume = "109",
pages = "189--192",
journal = "Journal of Bioscience and Bioengineering",
issn = "1389-1723",
publisher = "The Society for Biotechnology, Japan",
number = "2",
}