TY - JOUR
T1 - Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome
AU - Watanabe, Atsuyuki
AU - Fukushima Kusano, Kengo
AU - Morita, Hiroshi
AU - Miura, Daiji
AU - Sumida, Wakako
AU - Hiramatsu, Shigeki
AU - Banba, Kimikazu
AU - Nishii, Nobuhiro
AU - Nagase, Satoshi
AU - Nakamura, Kazufumi
AU - Sakuragi, Satoru
AU - Ohe, Tohru
PY - 2006/7
Y1 - 2006/7
N2 - Aims: Arrhythmic storm or repetitive ventricular arrhythmia (VA) has been occasionally observed in Brugada syndrome (BS). A beta-adrenergic stimulator [isoproterenol (ISP)] has been reported to suppress this arrhythmic storm in sporadic cases. Accordingly, we investigated the antiarrhythmic effects of ISP infusion in consecutive BS patients with arrhythmic storm or repetitive VA. Methods and results: Seven BS patients with arrhythmic storm were studied. Intravenous ISP was administered as a bolus injection (1-2 μg), followed by continuous infusion (0.15 μg/min). Arrhythmic storm or repetitive VA was suppressed immediately after the bolus administration of ISP, which was followed by continuous infusion of low-dose ISP for 1-3 days. In all patients, ST-elevation decreased in right precordial leads. In six of the seven patients, VA subsided after the discontinuance of ISP. RR interval was shortened and ST-elevation in right precordial leads was decreased after ISP bolus injection. ST-elevation in right precordial leads remained decreased during continuous ISP infusion, whereas the RR interval returned to the control level. Conclusion: Continuous administration of low-dose ISP may be effective for the suppression of repetitive VA occurrence in patients with BS.
AB - Aims: Arrhythmic storm or repetitive ventricular arrhythmia (VA) has been occasionally observed in Brugada syndrome (BS). A beta-adrenergic stimulator [isoproterenol (ISP)] has been reported to suppress this arrhythmic storm in sporadic cases. Accordingly, we investigated the antiarrhythmic effects of ISP infusion in consecutive BS patients with arrhythmic storm or repetitive VA. Methods and results: Seven BS patients with arrhythmic storm were studied. Intravenous ISP was administered as a bolus injection (1-2 μg), followed by continuous infusion (0.15 μg/min). Arrhythmic storm or repetitive VA was suppressed immediately after the bolus administration of ISP, which was followed by continuous infusion of low-dose ISP for 1-3 days. In all patients, ST-elevation decreased in right precordial leads. In six of the seven patients, VA subsided after the discontinuance of ISP. RR interval was shortened and ST-elevation in right precordial leads was decreased after ISP bolus injection. ST-elevation in right precordial leads remained decreased during continuous ISP infusion, whereas the RR interval returned to the control level. Conclusion: Continuous administration of low-dose ISP may be effective for the suppression of repetitive VA occurrence in patients with BS.
KW - Brugada syndrome
KW - Isoproterenol
KW - Ventricular arrhythmia
UR - https://www.scopus.com/pages/publications/33745445929
UR - https://www.scopus.com/pages/publications/33745445929#tab=citedBy
U2 - 10.1093/eurheartj/ehl060
DO - 10.1093/eurheartj/ehl060
M3 - Article
C2 - 16760208
AN - SCOPUS:33745445929
SN - 0195-668X
VL - 27
SP - 1579
EP - 1583
JO - European Heart Journal
JF - European Heart Journal
IS - 13
ER -