Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

Takaaki Kubota; Yuichiro Ishiguro; Azusa Takahashi-Nakaguchi; Jane Fromont; Tohru Gonoi; Jun'Ichi Kobayashi

doi:10.1016/j.bmcl.2012.10.109

Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

Takaaki Kubota, Yuichiro Ishiguro, Azusa Takahashi-Nakaguchi, Jane Fromont, Tohru Gonoi, Jun'Ichi Kobayashi

研究成果 › 査読

9 被引用数 (Scopus)

抄録

Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.

本文言語	English
ページ（範囲）	244-247
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	23
号	1
DOI	https://doi.org/10.1016/j.bmcl.2012.10.109
出版ステータス	Published - 1月 1 2013
外部発表	はい

ASJC Scopus subject areas

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/j.bmcl.2012.10.109

他のファイルとリンク

引用スタイル

@article{f08ea526202e4e6ca3cfe0810befa843,

title = "Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.",

abstract = "Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.",

keywords = "Antimicrobial activity, Dimeric fatty-acid derivative, Manzamenones L-N, Marine sponge, Plakortis sp.",

author = "Takaaki Kubota and Yuichiro Ishiguro and Azusa Takahashi-Nakaguchi and Jane Fromont and Tohru Gonoi and Jun'Ichi Kobayashi",

note = "Funding Information: We thank Mr. Z. Nagahama for his help with sponge collection, and Ms. S. Oka, Instrumental Analysis Division, Equipment Management Center, Creative Reseach Institution, Hokkaido University, for measurements of ESIMS. This work was supported by the Akiyama Life Sience Foundation, the Suhara Memorial Foundation, and Grant-in-Aid for Scientific Research on Innovative Areas (Biosynthetic Machinery) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. ",

year = "2013",

month = jan,

day = "1",

doi = "10.1016/j.bmcl.2012.10.109",

language = "English",

volume = "23",

pages = "244--247",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "1",

}

TY - JOUR

T1 - Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

AU - Kubota, Takaaki

AU - Ishiguro, Yuichiro

AU - Takahashi-Nakaguchi, Azusa

AU - Fromont, Jane

AU - Gonoi, Tohru

AU - Kobayashi, Jun'Ichi

N1 - Funding Information: We thank Mr. Z. Nagahama for his help with sponge collection, and Ms. S. Oka, Instrumental Analysis Division, Equipment Management Center, Creative Reseach Institution, Hokkaido University, for measurements of ESIMS. This work was supported by the Akiyama Life Sience Foundation, the Suhara Memorial Foundation, and Grant-in-Aid for Scientific Research on Innovative Areas (Biosynthetic Machinery) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.

AB - Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data. Manzamenones L-N (1-3) were new dimeric fatty-acid derivatives consisting of a tetrahydroindenone with three carboxy groups and two hexadecanyl chains. Manzamenones M (2) and N (3) showed antimicrobial activity against several bacteria and fungi.

KW - Antimicrobial activity

KW - Dimeric fatty-acid derivative

KW - Manzamenones L-N

KW - Marine sponge

KW - Plakortis sp.

UR - http://www.scopus.com/inward/record.url?scp=84870997899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870997899&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2012.10.109

DO - 10.1016/j.bmcl.2012.10.109

M3 - Article

C2 - 23186727

AN - SCOPUS:84870997899

SN - 0960-894X

VL - 23

SP - 244

EP - 247

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

抄録

ASJC Scopus subject areas

UN SDG

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル