Microstructure evolution in Stöber-type silica nanoparticles and their in vitro apatite deposition

Song Chen, Akiyoshi Osaka, Satoshi Hayakawa, Kanji Tsuru, Eiji Fujii, Koji Kawabata


38 被引用数 (Scopus)


Prepared via Stöber-type sol-gel routes were three types of silica particles of <1 μm in size: pure silica, Ca-involving silica, and chitosan/alginate-coated silica with a polymershell-silica core structure. Calcium ions were impregnated in the organic layers of the polymer-coated silica particle. The sol-gel procedure was applied to tetraethoxysilane dissolved in an ethanol/water mixture, while Ca-silica was derived from CaCl 2-containing ethanol/water solutions. Scanning and transmission electron micrograph analyses indicated that those silica particles consisted of ~10 nm primary particles, the Ca-silica particles (~500 nm) were larger than the Ca-free ones (~200 nm) and that their size increased with the Ca concentration in the precursor solutions. From 1H- and 29Si- magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectra and 29Si cross-polarization NMR spectra, the mechanism of primary particle agglomeration and degradation of the secondary particles in saline were discussed in terms of the content of H2O molecules and >Si-OH as well as hydrogen bonding interactions among them. In addition, the Ca-silica and core-shell silica deposited apatite in Kokubo's simulated body fluid. Thus, the present Ca-silica and polymer-coated silica particles were suggested to be applicable to injectable bone fillers for bone generation.

ジャーナルJournal of Sol-Gel Science and Technology
出版ステータスPublished - 12月 2008

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • セラミックおよび複合材料
  • 化学 (全般)
  • 生体材料
  • 凝縮系物理学
  • 材料化学


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