Multitracer screening for in vivo element-element interrelations: Part I: Uptake of ⁵⁴Mn, ⁴⁶Sc, ⁵⁹Fe, ⁵⁸Co, ⁶⁵Zn, ⁷⁵Se, ⁸³Rb, ⁸⁵Sr and ⁸⁸Zr by brain and other organs of mice bred under Mn-deficient, -adequate and -excessive diets

Radioactive multitracer technique was applied to study the screening of in vivo interrelations between radioactive tracers (⁴⁶Sc, ⁵⁹Fe, ⁵⁸Co, ⁶⁵Zn, ⁷⁵Se, ⁸³Rb, ⁸⁵Sr and ⁸⁸Zr) and stable Mn species. Comparative uptake rates were examined in the blood, 9 organs (thymus, lung, cardiac muscle, spleen, pancreas, kidney, liver, testes and bone) and 8 brain regions (cerebral cortex, striatum, hippocampus, thalamus and hypothalamus, midbrain, cerebellum, pons and medulla, olfactory bulb) using the 3-weeks-old mice fed the Mn-deficient, -adequate or -excessive diets with Mn concentration from 0.4 to 300.4 ppm. Significant diet-related differences were found for ⁶⁵Zn uptake in some organs. The dietary Mn-deficient state induced increase Zn absorption in thymus and lung in short-time span (during 48 hours after injection). On the other hand, no significant diet-related differences were observed in any brain regional uptake rates except for ⁵⁴Mn uptake rate. The screening results are expected to give us new findings concerning the diet-related element-element interrelations in living bodies.