Pachydermoperiostosis associated with juvenile polyps of the stomach and gastric adenocarcinoma

Fusao Ikeda, Hiroyuki Okada, Motowo Mizuno, Hirofumi Kawamoto, Nobuaki Okano, Hiroaki Okazaki, Shuji Hamazaki, Yasushi Shiratori

研究成果査読

25 被引用数 (Scopus)

抄録

Pachydermoperiostosis (PDP) is a rare syndrome, and the presence of digital clubbing, radiographic periostosis, and coarse facial features are the main diagnostic criteria. Here, we report patient with the primary form of PDP in whom juvenile polyps and gastric cancer developed within 9 years of follow-up. A 27-year-old Japanese man, diagnosed as having the primary form of PDP at 14 years of age, was referred to our department for assessment of chronic anemia. On upper gastrointestinal endoscopic examination, multiple polypoid lesions with a huge polyp were found in the stomach, and biopsy findings indicated juvenile polyps, although no polypoid lesion had been present at the age of 18 years. Bleeding from these polyps was suspected, and endoscopic mucosal resection of the polypoid lesions was performed. Histology of the huge polyp showed hamartoma, adenoma, and adenocarcinoma in part. This is the first case report of the primary form of PDP associated with gastric cancer. In this patient, juvenile polyps and gastric cancer developed within 9 years of follow-up, indicating that the primary form of PDP may be a high risk factor for gastric cancer, and that periodical follow-up with upper gastrointestinal endoscopy is important.

本文言語English
ページ(範囲)370-374
ページ数5
ジャーナルJournal of Gastroenterology
39
4
DOI
出版ステータスPublished - 4月 2004

ASJC Scopus subject areas

  • 消化器病学

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