Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

Yuka Sogabe; Katsuya Miyatani; Rieko Goto; Gengo Ishii; Kohichi Ohshima; Yasuharu Sato

doi:10.1007/s10384-012-0170-3

Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

Yuka Sogabe, Katsuya Miyatani, Rieko Goto, Gengo Ishii, Kohichi Ohshima, Yasuharu Sato

研究成果 › 査読

33 被引用数 (Scopus)

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Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.

本文言語	English
ページ（範囲）	511-514
ページ数	4
ジャーナル	Japanese Journal of Ophthalmology
巻	56
号	5
DOI	https://doi.org/10.1007/s10384-012-0170-3
出版ステータス	Published - 9月 2012

ASJC Scopus subject areas

眼科学

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10.1007/s10384-012-0170-3

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title = "Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease",

abstract = "Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.",

keywords = "IgG4-related disease, Infraorbital nerve, Nerve tumor, Orbital tumor, Trigeminal nerve lesion",

author = "Yuka Sogabe and Katsuya Miyatani and Rieko Goto and Gengo Ishii and Kohichi Ohshima and Yasuharu Sato",

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T1 - Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

AU - Sogabe, Yuka

AU - Miyatani, Katsuya

AU - Goto, Rieko

AU - Ishii, Gengo

AU - Ohshima, Kohichi

AU - Sato, Yasuharu

PY - 2012/9

Y1 - 2012/9

N2 - Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.

AB - Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.

KW - IgG4-related disease

KW - Infraorbital nerve

KW - Nerve tumor

KW - Orbital tumor

KW - Trigeminal nerve lesion

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Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

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